Successful Treatment of a Pediatric Patient with High-dose Colchicine Intake and Intoxication Findings by Hemoperfusion

Rabia Kuş, Mey Talip, Alper Kaçar, Emine Türkkan, Hüseyin Dağ

University Of Health Sciences Dr. Cemil Taşcıoğlu City Hospital, Pediatrics, Istanbul, Türkiye

Keywords: Colchicine, intoxication, hemoperfusion

Abstract

Colchicine is used in treating many rheumatological diseases and is widely prescribed in children. Its use specifically aims to prevent familial Mediterranean fever (FMF) attacks and amyloidosis prophylaxis. Colchicine’s therapeutic range is extremely narrow. It may cause fatal effects when taken at toxic doses. Since the plasma volume of distribution is very high, it is necessary to rapidly intervene for elimination from the body in case of toxicity with colchicine. In this case report, a 3.5-year-old patient with severe high-dose colchicine intake developed intoxication findings. Then, this patient successfully underwent hemoperfusion and recovered without sequelae.

Cite this article as: Kus R, Talip M, Kacar A, Turkkan E, Dag H. Successful Treatment of a Pediatric Patient with High-dose Colchicine Intake and Intoxication Findings by Hemoperfusion. Pediatr Acad Case Rep. 2023;2(2):56-59.

Conflict of Interest

The authors declared no conflicts of interest with respect to authorship and/or publication of the article.

Financial Disclosure

The authors received no financial support for the research and/or publication of this article.