Thrombotic Microangiopathy-A Diagnostic Dilemma
Amit Agarwal
, Tejan Bhatt
Madhukar Rainbow Children's Hospital, Division Of Pediatric Nephrology Department Of Pediatrics, New Delhi, India
Keywords: Thrombotic Microangiopathy, Autoimmune Hemolytic anemia, Anti-factor H antibodies, Antinuclear antibodies, ADAMTS13
Abstract
In India, approximately 50% of thrombotic microangiopathy (TMA) cases are caused by antibodies against Factor H complement. We describe a child who initially presented with features of autoimmune hemolytic anemia and later during the follow up evolved into full-blown TMA. While evaluation, he had antibodies against complement factor H and sub-endothelial deposits on electron microscopy of kidney biopsy, which in the presence of antinuclear antibodies and low complement C3 and C4 suggests an underlying lupus like disease. He also had low levels of ADAMTS13 levels. Thus, clearly more than one underlying etiology of TMA contribute to his disease.
Cite this article as: Agarwal A, Bhatt T. Thrombotic Microangiopathy-A Diagnostic Dilemma. Pediatr Acad Case Rep. 2025;4(2):36-39.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
The parents’ of this patient consent was obtained for this study.
The authors declared no conflicts of interest with respect to authorship and/or publication of the article.
The authors received no financial support for the research and/or publication of this article.