A case of Type 1 Diabetes Mellitus with Klinefelter’s Syndrome
Eren Er1
, Sibel T. Kınık2
1Baskent University, Faculty Of Medicine, Department Of Pediatrics, Ankara, Turkiye
2Baskent University, Faculty Of Medicine, Department Of Pediatric Endocrinlogy, Ankara, Turkiye
Keywords: 1 Diabetes, Klinefelter’s Syndrome
Abstract
Type 1 diabetes mellitus (T1DM) is a model of chronic autoimmune disease beginning with genetic susceptibility in affected individuals and progressing to autoimmune destruction of β cells, precipitated by environmental insult. Some of the patients with T1DM have associated genetic disorders, such as Klinefelter’s syndrome (KS), Down’s syndrome and Turner’s syndrome. This paper reports a case of T1DM accompanied by KS. The patient was a 14-year-old male who had been confirmed by absolute insulin deficiency and positive glutamic acid decarboxylase antibody (GADA). After chromosome analysis was performed because of the delay in his puberty, he was diagnosed with Klinefelter’s syndrome, 47 XXY karyotype, at his follow-up.
Cite this article as: Er E, Kinik S. A case of Type 1 Diabetes Mellitus with Klinefelter’s Syndrome. Pediatr Acad Case Rep. 2023;2(1):3-5.
The parents’ of this patient consent was obtained for this study.
The authors declared no conflicts of interest with respect to authorship and/or publication of the article.
The authors received no financial support for the research and/or publication of this article.